Article
p53 protein accumulation and p53 gene mutation in esophageal carcinoma. A molecular and immunohistochemical study with clinicopathologic correlations.
Cancer - 1 Feb 1997
Coggi G, Bosari S, Roncalli M, Graziani D, Bossi P, Viale G, Buffa R, Ferrero S, Piazza M, Blandamura S, Segalin A, Bonavina L, Peracchia A
Abstract excerpt
BACKGROUND: p53 gene mutation and p53 protein accumulation are common in human cancer. However, their clinical significance is controversial and p53 accumulation may not correlate with gene mutation. The current study investigates the occurrence of p53 alterations in esophageal carcinoma, the correlation between the analyses at the gene and protein level, and their prognostic significance. METHODS: A series of 74...
Topics
- Adenocarcinoma
- Barrett Esophagus
- Carcinoma
- Carcinoma, Squamous Cell
- DNA Probes
- Esophageal Neoplasms
- Female
- Genes, p53
- Humans
- Immunohistochemistry