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Article

p53 Mutation status predicts pathological response to chemoradiotherapy in locally advanced esophageal cancer.

Annals of surgical oncology - 1 Mar 2010

Makino Tomoki, Yamasaki Makoto, Miyata Hiroshi, Yoshioka Setsuko, Takiguchi Shuji, Fujiwara Yoshiyuki, Nakajima Kiyokazu, Nishida Toshirou, Mori Masaki, Doki Yuichiro

Abstract excerpt

BACKGROUND AND OBJECTIVES: The p53 gene promotes cell-cycle arrest and apoptosis upon DNA damage and is associated with chemo- and radiosensitivity of cancer cells. However, its clinical significance has not been confirmed, especially in squamous cell carcinoma of the esophagus (ESCC). We investigated the correlation between p53 disorders (gene mutation and protein accumulation) and the effects of...

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Identifiers

PMID: 19885698
DOI: 10.1245/s10434-009-0786-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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