Article
Characterisation of p53 status at the gene, chromosomal and protein levels in oesophageal adenocarcinoma.
British journal of cancer - 3 Nov 2003
Doak S H, Jenkins G J S, Parry E M, Griffiths A P, Shah V, Baxter J N, Parry J M
Abstract excerpt
p53 mutations and loss of heterozygosity have been commonly associated with oesophageal adenocarcinoma. In this investigation, the p53 status of a Welsh population of Barrett's-associated oesophageal adenocarcinomas were fully characterised at the gene sequence, chromosomal, mRNA and protein levels. In total, 31 tumours were examined for p53 gene sequence mutations using RFLP with sequencing, allelic loss of the...
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