Article
Fungal Ku prevents permanent cell cycle arrest by suppressing DNA damage signaling at telomeres
4 Feb 2015
Abstract excerpt
The Ku heterodimer serves in the initial step in repairing DNA double-strand breaks by the non-homologous end-joining pathway. Besides this key function, Ku also plays a role in other cellular processes including telomere maintenance. Inactivation of Ku can lead to DNA repair defects and telomere aberrations. In model organisms where Ku has been studied, inactivation can lead to DNA repair defects and telomere...
Topics
Join the communities discussing this publication.