Article
The p53 status of Chinese hamster V79 cells frequently used for studies on DNA damage and DNA repair.
Nucleic acids research - 1 Mar 1997
Chaung W, Mi L J, Boorstein R J
Abstract excerpt
Chinese hamster lung fibroblast V79 cells have been widely used in studies of DNA damage and DNA repair. Since the p53 gene is involved in normal responses to DNA damage, we have analyzed the molecular genetics and functional status of p53 in V79 cells and primary Chinese hamster embryonic fibroblast (CHEF) cells. The coding product of the p53 gene in CHEF cells was 76 and 75% homologous to human and mouse p53...
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