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Stable formation of mutated p53 multimers in a Chinese hamster cell line causes defective p53 nuclear localization and abrogates its residual function.

Journal of cellular biochemistry - 15 Aug 2006

Ottaggio Laura, Campomenosi Paola, Fronza Gilberto, Menichini Paola, Miele Mariangela, Moro Francesca, Viaggi Silvia, Zunino Annalisa, Abbondandolo Angelo

Abstract excerpt

We have previously described a methotrexate-resistant cell line (MTX M) characterized by amplified dihydrofolate reductase (DHFR) genes, cytoplasmic p53 localization, and p53 stable tetramers. To investigate the p53 functionality in MTX M, the effect of chemical/physical agents was studied. In MTX M cells, DNA damage did not induce p53 or mdm-2 protein, while in the parental V79 cells, a residual p53 activity was...

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PMID: 16598767
DOI: 10.1002/jcb.20921

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DHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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