Article
The heparin-binding domain and V region of fibronectin regulate apoptosis by suppression of p53 and c-myc in human primary cells.
The Journal of biological chemistry - 8 Mar 2002
Kapila Yvonne L, Wang Shaohui, Dazin Paul, Tafolla Elizabeth, Mass Marc J
Abstract excerpt
In apoptosis the tumor suppressor p53 and the c-myc proto-oncogene are usually up-regulated. We show a novel alternative pathway of apoptosis in human primary cells that is mediated by transcriptionally dependent decreases in p53 and c-Myc and decreases in p21. This pathway is regulated by the alternatively spliced V region and high-affinity heparin-binding domain of fibronectin. Requirements for c-Myc, p53, and...
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