Article
Accumulation of somatic hypermutation and antigen-driven selection in rapidly cycling surface Ig+ germinal center (GC) B cells which occupy GC at a high frequency during the primary anti-hapten response in mice.
European journal of immunology - 1 Jan 1997
Kimoto H, Nagaoka H, Adachi Y, Mizuochi T, Azuma T, Yagi T, Sata T, Yonehara S, Tsunetsugu-Yokota Y, Taniguchi M, Takemori T
Abstract excerpt
Well-developed germinal centers (GC) contain rapidly dividing surface immunoglobulin-negative (sIg-) B cells (centroblasts), and most of their progeny are sIg+ B cells (centrocytes) in a resting state. It has been predicted that somatic hypermutation occurs in centroblasts, whereas antigen-driven...
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