Sequential triggering of apoptosis, somatic mutation and isotype switch during germinal center development.

doi:10.1006/smim.1996.0021

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Article

Sequential triggering of apoptosis, somatic mutation and isotype switch during germinal center development.

Seminars in immunology - 1 Jun 1996

Liu Y J, Arpin C, de Bouteiller O, Guret C, Banchereau J, Martinez-Valdez H, Lebecque S

Abstract excerpt

Using an approach similar to that used to study primary B-lymphocyte development within bone marrow and primary T-lymphocyte development within thymus, the peripheral B-cell maturation pathway within secondary lymphoid tissue (human tonsils) was analysed on the expression of discrete surface anti...

Topics

Apoptosis
B-Lymphocytes
CD40 Ligand
Germinal Center
Humans
Immunoglobulin Class Switching
Membrane Glycoproteins
Mutation

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