Article
Somatic mutations and affinity maturation are impaired by excessive numbers of T follicular helper cells and restored by Treg cells or memory T cells.
European journal of immunology - 1 Nov 2015
Preite Silvia, Baumjohann Dirk, Foglierini Mathilde, Basso Camilla, Ronchi Francesca, Fernandez Rodriguez Blanca M, Corti Davide, Lanzavecchia Antonio, Sallusto Federica
Abstract excerpt
We previously reported that Cd3e-deficient mice adoptively transferred with CD4(+) T cells generate high numbers of T follicular helper (Tfh) cells, which go on to induce a strong B-cell and germinal center (GC) reaction. Here, we show that in this system, GC B cells display an altered distribution between the dark and light zones, and express low levels of activation-induced cytidine deaminase. Furthermore, GC B...
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