Article
A germinal center-independent pathway generates unswitched memory B cells early in the primary response.
The Journal of experimental medicine - 12 Mar 2012
Taylor Justin J, Pape Kathryn A, Jenkins Marc K
Abstract excerpt
Memory B cells can be produced from the classical germinal center (GC) pathway or a less understood GC-independent route. We used antigen-based cell enrichment to assess the relative contributions of these pathways to the polyclonal memory B cell pool. We identified a CD38(+) GL7(+) B cell precursor population that differentiated directly into IgM(+) or isotype-switched (sw) Ig(+) memory B cells in a...
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