Article
Immunization-induced perturbation of human blood plasma cell pool: progressive maturation, IL-6 responsiveness, and high PRDI-BF1/BLIMP1 expression are critical distinctions between antigen-specific and nonspecific plasma cells.
Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 2006
González-García Inés, Ocaña Esther, Jiménez-Gómez Gema, Campos-Caro Antonio, Brieva José A
Abstract excerpt
The present study shows that reimmunization with tetanus toxoid (tet) caused a transient increase of the human blood plasma cell (PC) pool, detectable from 6th to 15th day postboost, as well as the temporal alteration of several PC features. Labeling of specific PC with FITC-tet C fragment (tetC)...
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