Rsa I polymorphism at the cytochrome P4502E1 locus is not related to the risk of alcohol-related severe liver disease.

doi:10.1111/j.1600-0676.1996.tb00766.x

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Article

Rsa I polymorphism at the cytochrome P4502E1 locus is not related to the risk of alcohol-related severe liver disease.

Liver - 1 Dec 1996

Agúndez J, Ladero J, Díaz-Rubio M, Benítez J

Abstract excerpt

Ethanol-inducible cytochrome P4502E1 is the main pathway in the non-alcohol dehydrogenase oxidation of ethanol. Its coding gene, CYP2E1, is polymorphic at the Rsa I restriction site in the 5'-flanking region. The mutant genotype c2c2 has a higher transcriptional activity than the genotype c1c1 or...

Topics

Adult
Aged
Aged, 80 and over
Alcoholism
Alleles
Cytochrome P-450 CYP2E1
Female
Humans
Liver Diseases
Male
Middle Aged
Mutation
Polymorphism, Genetic
Risk Factors
Spain

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