Article
Genetic polymorphism of cytochrome P4502E1 and risk of alcoholic liver disease in Caucasians.
Pharmacogenetics - 1 Dec 1995
Pirmohamed M, Kitteringham N R, Quest L J, Allott R L, Green V J, Gilmore I T, Park B K
Abstract excerpt
Genetic factors may be of importance in determining inter-individual susceptibility to alcoholic liver disease (ALD). Among the candidate genes which have been considered to be important are those which code for enzymes involved in alcohol metabolism. Cytochrome P4502E1 (CYP2E1) metabolizes alcoh...
Topics
- Alcoholism
- Alleles
- Base Sequence
- Case-Control Studies
- Cytochrome P-450 CYP2E1
- Cytochrome P-450 Enzyme System
- DNA Primers
- Ethanol
- Female
- Gene Frequency
- Humans
- Liver Diseases, Alcoholic
- Male
- Molecular Sequence Data
- Odds Ratio
- Oxidoreductases, N-Demethylating
- Pharmacogenetics
- Polymerase Chain Reaction