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Article

RsaI polymorphism at the cytochrome P4502E1 locus and risk of hepatocellular carcinoma.

Gut - 1 Aug 1996

Ladero J M, Agúndez J A, Rodríguez-Lescure A, Diaz-Rubio M, Benítez J

Abstract excerpt

BACKGROUND: CYP2E1, the coding gene for the ethanol inducible cytochrome P4502E1, is polymorphic at the RsaI restriction site in the 5' flanking region. The mutant allele c2 has a higher transcriptional activity than the wild-type gene c1. P4502E1 catalyses the activation of several environmental carcinogens at a rate that is increased, if only moderately, by longterm ethanol intake. AIMS: To establish the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 8977352
DOI: 10.1136/gut.39.2.330
PMCID: PMC1383320

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Source receipt: pubmed, retrieved 7 Sept 2026.

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RsaI polymorphism at the cytochrome P4502E1 locus and risk of hepatocellular carcinoma.PMID 8977352Read ↗

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