Article
RsaI polymorphism at the cytochrome P4502E1 locus and risk of hepatocellular carcinoma.
Gut - 1 Aug 1996
Ladero J M, Agúndez J A, Rodríguez-Lescure A, Diaz-Rubio M, Benítez J
Abstract excerpt
BACKGROUND: CYP2E1, the coding gene for the ethanol inducible cytochrome P4502E1, is polymorphic at the RsaI restriction site in the 5' flanking region. The mutant allele c2 has a higher transcriptional activity than the wild-type gene c1. P4502E1 catalyses the activation of several environmental...
Topics
- Adult
- Aged
- Aged, 80 and over
- Alcoholism
- Alleles
- Carcinoma, Hepatocellular
- Case-Control Studies
- Cytochrome P-450 Enzyme System
- Endodeoxyribonucleases
- Female
- Genes
- Humans
- Liver Neoplasms
- Male
- Odds Ratio
- Polymorphism, Restriction Fragment Length
- Risk Factors
- Spain