Article
Genetic polymorphisms of ADH2, ADH3, CYP4502E1 Dra-I and Pst-I, and ALDH2 in Spanish men: lack of association with alcoholism and alcoholic liver disease.
Journal of hepatology - 1 Nov 2004
Vidal Francesc, Lorenzo Alfons, Auguet Teresa, Olona Montserrat, Broch Montserrat, Gutiérrez Cristina, Aguilar Carmen, Estupiñà Pere, Santos Mauro, Richart Cristóbal
Abstract excerpt
BACKGROUND/AIMS: The relationship between polymorphisms at the alcohol dehydrogenase 2 (ADH(2)), ADH(3), CYP(450)2E1 and aldehyde dehydrogenase 2 (ALDH(2)) loci and the individual predisposition to alcoholism and alcoholic liver disease in Caucasians is controversial. METHODS: We determined the genotypes of ADH(2), ADH(3), CYP(450)2E1 (Pst-I and Dra-I) and ALDH(2) in 519 male Spaniards: 264 alcoholic subjects (47...
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