Article
Polymorphism at the P450IIE1 locus is not associated with alcoholic liver disease in Caucasian men.
Alcoholism, clinical and experimental research - 1 Feb 1995
Carr L G, Hartleroad J Y, Liang Y, Mendenhall C, Moritz T, Thomasson H
Abstract excerpt
Because alcoholic hepatitis and cirrhosis, well-known complications of alcohol abuse, do not occur in all alcoholics, genetic factors such as differences in alcohol-metabolizing enzymes may play a role in the development of alcoholic liver disease. Cytochrome P450IIE1 catalyzes the oxidation of e...
Topics
- Adult
- Aged
- Alleles
- Chromosome Mapping
- Cytochrome P-450 CYP2E1
- Cytochrome P-450 Enzyme System
- Ethanol
- Gene Frequency
- Genotype
- Heterozygote
- Homozygote
- Humans
- Liver Cirrhosis, Alcoholic
- Male
- Middle Aged
- Oxidoreductases, N-Demethylating
- Polymorphism, Genetic