Article
Interaction between certain major histocompatibility complex class II and T-cell receptor V beta alleles promotes the antibody production to extractable nuclear antigen-related peptides.
Human immunology - 1 Jan 1997
Youinou P, Semana G, Muller S, Piette J C, Guillevin L, Jouquan J, Salmon D, Salmon J, Genetet B, Bach J F
Abstract excerpt
Our objective was to study the interaction between major histocompatibility complex (MHC) class II and T-cell receptor (TCR) alleles in the recognition of extractable nuclear antigen-derived peptides in 32 patients with systemic lupus erythematosus and 173 of their family members. MHC genes were analyzed using sequence specific oligonucleotides, and TCR beta-chain gene polymorphism using restriction...
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