Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MHC class II associations with autoantibody and T cell immune responses to the scleroderma autoantigen topoisomerase I.

Journal of autoimmunity - 1 Dec 2000

Rands A L, Whyte J, Cox B, Hall N D, McHugh N J

Abstract excerpt

Topoisomerase I (topo I) is a major autoantigen recognized by autoantibodies in about 30% of sera from patients with systemic sclerosis (SSc). Certain HLA-DRB1 and HLA-DQB1 alleles have been reported to be associated with autoantibody and T-cell responses to topo I suggesting a T-cell dependent process. We have examined the MHC class II allele associations with anti-topo I antibodies in 16 patients with SSc...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autoantibodies
Share to Autoantigens
Share to DNA Topoisomerases, Type I

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, MHC Class II

Share to HLA-DQ Antigens

Share to HLA-DQ beta-Chains

Share to HLA-DRB1 Chains

Share to Scleroderma, Systemic

Source

Identifiers

PMID: 11090244
DOI: 10.1006/jaut.2000.0447

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MHC class II associations with autoantibody and T cell immune responses to the scleroderma autoantigen topoisomerase I.PMID 11090244Read ↗

Autoreactive T cells to topoisomerase I in monozygotic twins discordant for systemic sclerosis.Semantic proximity Read ↗

T cell proliferative response induced by DNA topoisomerase I in patients with systemic sclerosis and healthy donors.Semantic proximity Read ↗

Different distribution of HLA class II alleles in anti-topoisomerase I autoantibody responders between silicosis and systemic sclerosis patients, with a common distinct amino acid sequence in the HLA-DQB1 domain.Semantic proximity Read ↗

Class II HLA associations with autoantibodies in scleroderma: a highly significant role for HLA-DP.Semantic proximity Read ↗

The HLA-DR and DQ genes control the autoimmune response to DNA topoisomerase I in systemic sclerosis (scleroderma).Semantic proximity Read ↗

HLA and autoantibodies define scleroderma subtypes and risk in African and European Americans and suggest a role for molecular mimicry.Semantic proximity Read ↗

Association of human leukocyte antigen class II genes with autoantibody profiles, but not with disease susceptibility in Japanese patients with systemic sclerosis.Semantic proximity Read ↗

Clonal autoantibodies identify microbial antigen as trigger of autoreactive B cells in systemic sclerosisSemantic proximity Read ↗

HLA and autoimmunity in scleroderma (systemic sclerosis).Semantic proximity Read ↗

Severe systemic sclerosis with anti-topoisomerase I antibodies is associated with an HLA-DRw11 allele.Semantic proximity Read ↗

Enhanced recognition of topoisomerase 1 upon DNA binding by a subset of anti-topoisomerase 1 autoantibodies in systemic sclerosisSemantic proximity Read ↗

Mapping of the immunodominant T cell epitopes of the protein topoisomerase I.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.