Article
HLA class II phenotype controls diversification of the autoantibody response in primary Sjögren's syndrome (pSS).
Clinical and experimental immunology - 1 Feb 1998
Rischmueller M, Lester S, Chen Z, Champion G, Van Den Berg R, Beer R, Coates T, McCluskey J, Gordon T
Abstract excerpt
The coexistence of anti-La (SS-B) and anti-Ro (SS-A) autoantibodies in pSS is probably explained by intermolecular spreading of autoimmunity toward different components of the La/Ro ribonucleoprotein (RNP). In order to evaluate the role of the HLA class II phenotype in controlling diversification...
Topics
- Alleles
- Autoantibodies
- Enzyme-Linked Immunosorbent Assay
- HLA-DR2 Antigen
- HLA-DR3 Antigen
- HLA-DR5 Antigen
- Haplotypes
- Histocompatibility Antigens Class II
- Humans
- Phenotype
- Sjogren's Syndrome