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Article

HLA class II phenotype controls diversification of the autoantibody response in primary Sjögren's syndrome (pSS).

Clinical and experimental immunology - 1 Feb 1998

Rischmueller M, Lester S, Chen Z, Champion G, Van Den Berg R, Beer R, Coates T, McCluskey J, Gordon T

Abstract excerpt

The coexistence of anti-La (SS-B) and anti-Ro (SS-A) autoantibodies in pSS is probably explained by intermolecular spreading of autoimmunity toward different components of the La/Ro ribonucleoprotein (RNP). In order to evaluate the role of the HLA class II phenotype in controlling diversification of this autoantibody response, 80 patients with pSS were typed by polymerase chain reaction sequence-specific...

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Source

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Identifiers

PMID: 9486405
DOI: 10.1046/j.1365-2249.1998.00504.x
PMCID: PMC1904917

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Source receipt: pubmed, retrieved 7 Sept 2026.

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