Article
Interaction between heat-shock protein 73 and HLA-DRB1 alleles associated or not with rheumatoid arthritis.
Arthritis and rheumatism - 1 Apr 2002
Auger Isabelle, Lepecuchel Lydia, Roudier Jean
Abstract excerpt
OBJECTIVE: HLA-DRB1 alleles whose third hypervariable region contains a QKRAA/QRRAA/RRRAA motif are associated with rheumatoid arthritis (RA) through unknown mechanisms. We previously demonstrated that the QKRAA motif was also expressed on the Escherichia coli 40-kd heat-shock protein (HSP) DnaJ. The QKRAA motif helps DnaJ bind its partner chaperone, the E coli 70-kd HSP DnaK. Furthermore, we observed that in...
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