Article
Cooperative association of T cell beta receptor and HLA-DQ alleles in the production of anti-Ro in systemic lupus erythematosus.
Clinical immunology and immunopathology - 1 Sept 1994
Scofield R H, Frank M B, Neas B R, Horowitz R M, Hardgrave K L, Fujisaku A, McArthur R, Harley J B
Abstract excerpt
The immunogenetics of the autoantibody response to Ro (or SS-A) have been explored in patients with systemic lupus erythematous. Data show that alleles of the T cell beta receptor and HLA-DQ loci are cooperatively associated with the presence of anti-Ro autoantibodies in systemic lupus erythematosus. Identification of HLA-DQ by oligonucleotide probe binding to polymerase chain reaction products demonstrates that...
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