Article
Antibody reactivity to the HRES-1 endogenous retroviral element identifies a subset of patients with systemic lupus erythematosus and overlap syndromes. Correlation with antinuclear antibodies and HLA class II alleles.
Arthritis and rheumatism - 1 Nov 1995
Perl A, Colombo E, Dai H, Agarwal R, Mark K A, Banki K, Poiesz B J, Phillips P E, Hoch S O, Reveille J D
Abstract excerpt
OBJECTIVE: To evaluate the correlation between the presence of antibodies to an endogenous retroviral element-encoded nuclear protein autoantigen, HRES-1, and the presence of other antinuclear antibodies and HLA class II alleles in patients with systemic lupus erythematosus (SLE) and overlap syndromes. METHODS: Antibody reactivities to native and recombinant proteins and synthetic peptides were assessed by...
Topics
- Alleles
- Antibodies, Antinuclear
- Antigens, Nuclear
- Autoantibodies
- Autoantigens
- Autoimmune Diseases
- Blotting, Western
- Cross Reactions
- HLA-DQ Antigens
- HLA-DR Antigens