Article
Cancer-associated mutations at the INK4a locus cancel cell cycle arrest by p16INK4a but not by the alternative reading frame protein p19ARF.
Proceedings of the National Academy of Sciences of the United States of America - 21 Jan 1997
Quelle D E, Cheng M, Ashmun R A, Sherr C J
Abstract excerpt
The INK4a gene, one of the most frequently disrupted tumor suppressor loci in human cancer, encodes two unrelated proteins, p16INK4a and p19ARF, each of which is capable of inducing cell cycle arrest. Splicing of alternative first exons (1 alpha vs. 1 beta) to a common second exon within INK4a generates mRNAs in which exon 2 sequences are translated in two different reading frames. One of the products, the cyclin...
Topics
- 3T3 Cells
- Alternative Splicing
- Animals
- Carrier Proteins
- Cell Cycle
- Cyclin-Dependent Kinase Inhibitor p16
- DNA, Neoplasm
- Exons
- Genes, Tumor Suppressor
- Mice
- Mutation