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Article

The tumor-suppressive functions of the human INK4A locus.

Cancer cell - 1 Oct 2003

Voorhoeve P Mathijs, Agami Reuven

Abstract excerpt

The INK4A locus is often inactivated in human cancer. INK4A encodes for p14ARF and p16INK4A that inhibit growth through p53 and pRb, respectively. We used RNA interference vectors in transformation assays of human primary cells to analyze tumor-suppressive functions. We first show that a concerted inactivation of pRb and p53 is required for transformation. We then demonstrate that loss of p14ARF enhances growth...

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Identifiers

PMID: 14585358
DOI: 10.1016/s1535-6108(03)00223-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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