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Article

Presymptomatic hippocampal atrophy in Alzheimer's disease. A longitudinal MRI study.

Brain : a journal of neurology - 1 Dec 1996

Fox N C, Warrington E K, Freeborough P A, Hartikainen P, Kennedy A M, Stevens J M, Rossor M N

Abstract excerpt

The hippocampal formation (HF) is known from pathological and MRI studies to be severely atrophied in established Alzheimer's disease. However, it is unclear when the earliest changes in the HF occur. We performed a longitudinal study of asymptomatic individuals at risk of autosomal dominant familial Alzheimer's disease in order to assess presymptomatic changes in the HF. Seven at risk members of a familial...

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Identifiers

PMID: 9010004
DOI: 10.1093/brain/119.6.2001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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