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Article

Hippocampal hyperactivation in presymptomatic familial Alzheimer's disease.

Annals of neurology - 1 Dec 2010

Quiroz Yakeel T, Budson Andrew E, Celone Kim, Ruiz Adriana, Newmark Randall, Castrillón Gabriel, Lopera Francisco, Stern Chantal E

Abstract excerpt

OBJECTIVE: The examination of individuals who carry fully penetrant genetic alterations that result in familial Alzheimer's disease (FAD) provides a unique model for studying the early presymptomatic disease stages. In AD, deficits in episodic and associative memory have been linked to structural and functional changes within the hippocampal system. This study used functional MRI (fMRI) to examine hippocampal...

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Identifiers

PMID: 21194156
DOI: 10.1002/ana.22105
PMCID: PMC3175143

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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