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Article

Distinct subtypes of Alzheimer's disease based on patterns of brain atrophy: longitudinal trajectories and clinical applications.

Scientific reports - 18 Apr 2017

Ferreira Daniel, Verhagen Chloë, Hernández-Cabrera Juan Andrés, Cavallin Lena, Guo Chun-Jie, Ekman Urban, Muehlboeck J-Sebastian, Simmons Andrew, Barroso José, Wahlund Lars-Olof, Westman Eric

Abstract excerpt

Atrophy patterns on MRI can reliably predict three neuropathological subtypes of Alzheimer's disease (AD): typical, limbic-predominant, or hippocampal-sparing. A method to enable their investigation in the clinical routine is still lacking. We aimed to (1) validate the combined use of visual rating scales for identification of AD subtypes; (2) characterise these subtypes at baseline and over two years; and (3)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28417965
DOI: 10.1038/srep46263
PMCID: PMC5394684

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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