MRI of hippocampal volume loss in early Alzheimer's disease in relation to ApoE genotype and biomarkers.

doi:10.1093/brain/awp007

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Article

MRI of hippocampal volume loss in early Alzheimer's disease in relation to ApoE genotype and biomarkers.

Brain : a journal of neurology - 1 Apr 2009

Schuff N, Woerner N, Boreta L, Kornfield T, Shaw L M, Trojanowski J Q, Thompson P M, Jack C R, Weiner M W

Abstract excerpt

Hippocampal volume change over time, measured with MRI, has huge potential as a marker for Alzheimer's disease. The objectives of this study were: (i) to test if constant and accelerated hippocampal loss can be detected in Alzheimer's disease, mild cognitive impairment and normal ageing over short periods, e.g. 6-12 months, with MRI in the large multicentre setting of the Alzheimer's Disease Neuroimaging...

Topics

Aged
Aged, 80 and over
Alzheimer Disease
Amyloid beta-Peptides
Apolipoproteins E
Biomarkers
Cognition Disorders
Disease Progression
Female
Genetic Predisposition to Disease
Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hippocampus

Humans

Magnetic Resonance Imaging

Male

Peptide Fragments

Polymorphism, Genetic

Psychiatric Status Rating Scales

Source

Open in PubMed Open full text

Identifiers

PMID: 19251758
DOI: 10.1093/brain/awp007
PMCID: PMC2668943

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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