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Article

Cortical atrophy in presymptomatic Alzheimer's disease presenilin 1 mutation carriers.

Journal of neurology, neurosurgery, and psychiatry - 1 May 2013

Quiroz Yakeel T, Stern Chantal E, Reiman Eric M, Brickhouse Michael, Ruiz Adriana, Sperling Reisa A, Lopera Francisco, Dickerson Bradford C

Abstract excerpt

BACKGROUND: Sporadic late-onset Alzheimer's disease (AD) dementia has been associated with a 'signature' of cortical atrophy in paralimbic and heteromodal association regions measured with MRI. OBJECTIVE: To investigate whether a similar pattern of cortical atrophy is present in presymptomatic presenilin 1 E280A mutation carriers an average of 6 years before clinical symptom onset. METHODS: 40 cognitively normal...

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Identifiers

PMID: 23134660
DOI: 10.1136/jnnp-2012-303299
PMCID: PMC3632663

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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