Article
A novel, transformation-relevant activation domain in Fos proteins.
Molecular and cellular biology - 1 Feb 1997
Funk M, Poensgen B, Graulich W, Jerome V, Müller R
Abstract excerpt
We have previously demonstrated that transformation by Fos is critically dependent on an intact DNA-binding domain (bZip) and a functional N-terminal transactivation motif (N-TM). We now show that a novel motif (C-terminal transactivation motif [C-TM]) near the C terminus also plays an important...
Topics
- 3T3 Cells
- Amino Acid Sequence
- Animals
- Cell Line
- Cell Transformation, Neoplastic
- Genes, fos
- Genetic Complementation Test
- Mice
- Molecular Sequence Data
- Moloney murine sarcoma virus
- Mutation
- Neoplastic Stem Cells
- Oncogene Proteins v-fos
- Proto-Oncogene Proteins c-fos
- Rats
- Recombinant Fusion Proteins
- Saccharomyces cerevisiae
- Transcriptional Activation