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Article

EBF contains a novel zinc coordination motif and multiple dimerization and transcriptional activation domains.

The EMBO journal - 15 Jun 1995

Hagman J, Gutch M J, Lin H, Grosschedl R

Abstract excerpt

Early B cell factor (EBF) was identified and cloned as a transcription factor expressed specifically in B lymphocytes and adipocytes. This protein was also identified as olfactory factor 1 (Olf-1) in olfactory neurons. In this study, we analyzed the structural requirements for DNA binding, homodimerization and transcriptional activation by EBF. A carboxyl-terminal region, containing a repeat of alpha-helices...

Topics

Amino Acid Sequence
Base Sequence
DNA
DNA Mutational Analysis
DNA-Binding Proteins
Molecular Sequence Data
Mutation
Protein Conformation
Protein Structure, Secondary
Trans-Activators
Transcriptional Activation

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Zinc

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Identifiers

PMID: 7796816
DOI: 10.1002/j.1460-2075.1995.tb07290.x
PMCID: PMC398409

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7796816-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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