Article

YAP and TAZ are transcriptional co-activators of AP-1 proteins and STAT3 during breast cellular transformation

2021-02-18

Abstract excerpt

<h4>ABSTRACT</h4> The YAP and TAZ paralogues are transcriptional co-activators recruited to target sites, primarily by TEAD proteins. Here, we show that YAP and TAZ are also recruited by JUNB and STAT3, key factors that mediate an epigenetic switch linking inflammation to cellular transformation. YAP and TAZ directly interact with JUNB and STAT3 via a WW domain important for transformation, co-occupy many target...

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Literature Corpus work: c086b23e-f1c3-5938-9a11-e9a621d81479
DOI: 10.1101/2021.02.18.431832

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