Article
Structure of the DNA-binding domains from NFAT, Fos and Jun bound specifically to DNA.
Nature - 5 Mar 1998
Chen L, Glover J N, Hogan P G, Rao A, Harrison S C
Abstract excerpt
The nuclear factor of activated T cells (NFAT) and the AP-1 heterodimer, Fos-Jun, cooperatively bind a composite DNA site and synergistically activate the expression of many immune-response genes. A 2.7-A-resolution crystal structure of the DNA-binding domains of NFAT, Fos and Jun, in a quaternary complex with a DNA fragment containing the distal antigen-receptor response element from the interleukin-2 gene...
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