Article
Structure of the DNA-binding domains from NFAT, Fos and Jun bound specifically to DNA.
Nature - 5 Mar 1998
Chen L, Glover J N, Hogan P G, Rao A, Harrison S C
Abstract excerpt
The nuclear factor of activated T cells (NFAT) and the AP-1 heterodimer, Fos-Jun, cooperatively bind a composite DNA site and synergistically activate the expression of many immune-response genes. A 2.7-A-resolution crystal structure of the DNA-binding domains of NFAT, Fos and Jun, in a quaternar...
Topics
- Amino Acid Sequence
- Animals
- Binding Sites
- Crystallography, X-Ray
- DNA
- DNA-Binding Proteins
- Gene Expression Regulation
- Humans
- Mice
- Models, Molecular
- Molecular Sequence Data
- Mutation
- NFATC Transcription Factors
- Nuclear Proteins
- Protein Conformation
- Proto-Oncogene Proteins c-fos
- Proto-Oncogene Proteins c-jun
- Recombinant Proteins