Article
Non-leucine residues in the leucine repeats of Fos and Jun contribute to the stability and determine the specificity of dimerization.
Nucleic acids research - 25 Feb 1991
Schuermann M, Hunter J B, Hennig G, Müller R
Abstract excerpt
Various transcription factors, including C/EBP, GCN4 and members of the Fos, Jun and Myc families have been shown to form highly specific complexes via alpha-helical structures referred to as leucine zippers. Experimental evidence has suggested that dimerization involves the formation of hydrophobic bonds between leucine residues in laterally aligned coiled coil structures. However, the specificity of interaction...
Topics
- Amino Acid Sequence
- Electrophoresis, Polyacrylamide Gel
- Leucine Zippers
- Molecular Sequence Data
- Mutation
- Oncogene Protein p65(gag-jun)
- Oncogene Proteins v-fos
- Oncogene Proteins, Viral
- Repetitive Sequences, Nucleic Acid
- Retroviridae Proteins, Oncogenic