Article
An autonomous N-terminal transactivation domain in Fos protein plays a crucial role in transformation.
The EMBO journal - 15 Mar 1994
Jooss K U, Funk M, Müller R
Abstract excerpt
To date, three functional domains have been defined in c-Fos and v-Fos proteins and have been shown to play a role in transactivation: the leucine zipper mediating hetero-dimerization, the basic DNA contact site, and a C-terminally located transactivation domain (C-TA) harbouring the HOB1 and HOB...
Topics
- 3T3 Cells
- Amino Acid Sequence
- Animals
- Base Sequence
- Binding Sites
- Cells, Cultured
- Conserved Sequence
- DNA Primers
- Humans
- Mice
- Molecular Sequence Data
- Mutation
- Proto-Oncogene Proteins c-fos
- Saccharomyces cerevisiae
- Sequence Homology, Amino Acid
- Transcriptional Activation
- Transformation, Genetic