Article
DNA binding and transactivation properties of Fos variants with homodimerization capacity.
Nucleic acids research - 1 Aug 1997
Porte D, Oertel-Buchheit P, John M, Granger-Schnarr M, Schnarr M
Abstract excerpt
The mammalian Fos and Fos-related proteins are unable to form homodimers and to bind DNA in the absence of a second protein, like c-Jun for example. In order to study the implications of hydrophobic point mutations in the c-Fox leucine zipper on DNA binding of the entire c-Fos protein, we have constructed and purified a set of Fos mutant proteins harboring one or several isoleucine or leucine residues in the five...
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