Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Both Jun and Fos contribute to transcription activation by the heterodimer.

Oncogene - 1 Jan 1990

Hirai S, Bourachot B, Yaniv M

Abstract excerpt

Comparison of the amino acid sequence of the three members of the mouse jun proto-oncogene family, c-jun, jun B and jun D, reveals several homologous segments. The most C-terminal of them including a leucine zipper motif and a cluster of basic amino acids was previously identified as the DNA binding domain. By deletion analysis, we show that three conserved domains in the N-terminal region are crucial for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosome Deletion
Share to DNA
Share to DNA-Binding Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to Proto-Oncogene Proteins

Share to Transcription Factors

Share to Transcriptional Activation

Share to Transfection

Source

Identifiers

PMID: 2108402

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Both Jun and Fos contribute to transcription activation by the heterodimer.PMID 2108402Read ↗

A novel, transformation-relevant activation domain in Fos proteins.Semantic proximity Read ↗

Non-leucine residues in the leucine repeats of Fos and Jun contribute to the stability and determine the specificity of dimerization.Semantic proximity Read ↗

An autonomous N-terminal transactivation domain in Fos protein plays a crucial role in transformation.Semantic proximity Read ↗

Trans-dominant negative mutants of Fos and Jun.Semantic proximity Read ↗

The transcription factor Fos: a Janus-type regulator in health and disease.Semantic proximity Read ↗

Structure of the DNA-binding domains from NFAT, Fos and Jun bound specifically to DNA.Semantic proximity Read ↗

DNA binding and transactivation properties of Fos variants with homodimerization capacity.Semantic proximity Read ↗

Transformation by FosB requires a trans-activation domain missing in FosB2 that can be substituted by heterologous activation domains.Semantic proximity Read ↗

Proto-Oncogenes of the <i><i>fos/jun</i></i> Family of Transcription Factors are Positive Regulators of Myeloid DifferentiationSemantic proximity Read ↗

The C-terminal domain of c-fos is required for activation of an AP-1 site specific for jun-fos heterodimers.Semantic proximity Read ↗

Induction of the AP-1 members c-Jun and JunB by TGF-β/Smad suppresses early Smad-driven gene activationSemantic proximity Read ↗

Bone development and inflammatory disease is regulated by AP-1 (Fos/Jun)Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.