C-terminal activating and inhibitory domains determine the transactivation potential of BSAP (Pax-5), Pax-2 and Pax-8.

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Article

C-terminal activating and inhibitory domains determine the transactivation potential of BSAP (Pax-5), Pax-2 and Pax-8.

The EMBO journal - 15 Apr 1996

Dörfler P, Busslinger M

Abstract excerpt

Pax-5 encodes the transcription factor BSAP which plays an essential role in early B cell development and midbrain patterning. In this study we have analysed the structural requirements for transcriptional activation by BSAP. In vitro mutagenesis and transient transfection experiments indicate th...

Topics

Alleles
Amino Acid Sequence
Animals
B-Lymphocytes
Base Sequence
DNA, Complementary
DNA-Binding Proteins
Enhancer Elements, Genetic
Frameshift Mutation
Genes, Reporter
Humans
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Nuclear Proteins

PAX2 Transcription Factor

PAX5 Transcription Factor

PAX8 Transcription Factor

Paired Box Transcription Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 8617244
PMCID: PMC450116

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8617244-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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C-terminal activating and inhibitory domains determine the transactivation potential of BSAP (Pax-5), Pax-2 and Pax-8.PMID 8617244Read ↗

Loss- and gain-of-function mutations reveal an important role of BSAP (Pax-5) at the start and end of B cell differentiation.Semantic proximity Read ↗

The Highly Conserved β-Hairpin of the Paired DNA-Binding Domain Is Required for Assembly of Pax-Ets Ternary ComplexesSemantic proximity Read ↗

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