Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

C-terminal activating and inhibitory domains determine the transactivation potential of BSAP (Pax-5), Pax-2 and Pax-8.

The EMBO journal - 15 Apr 1996

Dörfler P, Busslinger M

Abstract excerpt

Pax-5 encodes the transcription factor BSAP which plays an essential role in early B cell development and midbrain patterning. In this study we have analysed the structural requirements for transcriptional activation by BSAP. In vitro mutagenesis and transient transfection experiments indicate that the C-terminal serine/threonine/proline-rich region of BSAP contains a potent transactivation domain of 55 amino...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Amino Acid Sequence
Share to Base Sequence

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA-Binding Proteins

Share to DNA, Complementary

Share to Molecular Sequence Data

Share to Nuclear Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 8617244
PMCID: PMC450116

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

C-terminal activating and inhibitory domains determine the transactivation potential of BSAP (Pax-5), Pax-2 and Pax-8.PMID 8617244Read ↗

Loss- and gain-of-function mutations reveal an important role of BSAP (Pax-5) at the start and end of B cell differentiation.Semantic proximity Read ↗

The Highly Conserved β-Hairpin of the Paired DNA-Binding Domain Is Required for Assembly of Pax-Ets Ternary ComplexesSemantic proximity Read ↗

Requirements for selective recruitment of Ets proteins and activation of mb-1/Ig-alpha gene transcription by Pax-5 (BSAP).Semantic proximity Read ↗

Mapping of Pax-2 Transcription Activation DomainsSemantic proximity Read ↗

The Epstein-Barr virus promoter initiating B-cell transformation is activated by RFX proteins and the B-cell-specific activator protein BSAP/Pax5.Semantic proximity Read ↗

Histone acetyltransferase p300 acetylates Pax5 and strongly enhances Pax5-mediated transcriptional activity.Semantic proximity Read ↗

Transformation by FosB requires a trans-activation domain missing in FosB2 that can be substituted by heterologous activation domains.Semantic proximity Read ↗

Transcriptional regulation in early B cell development.Semantic proximity Read ↗

Phosphorylation of the transactivation domain of Pax6 by extracellular signal-regulated kinase and p38 mitogen-activated protein kinase.Semantic proximity Read ↗

The regulation of the B‐cell gene expression programme by Pax5Semantic proximity Read ↗

Differential regulation of sense and antisense promoter activity at the Csf1R locus in B cells by the transcription factor PAX5.Semantic proximity Read ↗

A novel, transformation-relevant activation domain in Fos proteins.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.