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Mutations induced by DNA double-strand breaks: the influence of genomic site.

Somatic cell and molecular genetics - 1 Jul 1996

Costa N D, Thacker J

Abstract excerpt

The transgenic CHO cell line PL61, carrying a recombinant SV40-gpt gene, was treated with restriction endonucleases to assess mutagenesis from defined DNA double-strand breaks. Mutations in gpt were measured under two conditions: a stringent condition where selection ensured that the closely-linked neo gene was retained functionally intact, or a relaxed condition without the requirement for neo gene function....

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PMID: 9000170
DOI: 10.1007/BF02369565

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