Article
Investigation of the mutagenic specificity of X-rays using a retroviral shuttle vector in CHO cells.
Environmental and molecular mutagenesis - 1 Jan 1992
Skandalis A, Grosovsky A J, Drobetsky E A, Glickman B W
Abstract excerpt
In some biological systems ionizing radiation appears to induce large deletions and rearrangements, while in others point mutations predominate the mutational spectrum. Moreover, while the point mutations are often randomly distributed, some systems exhibit "hot spots." Retroviral shuttle vectors are particularly useful for investigating the basis of these differences since the genetic target can be conveniently...
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