Article
Independently cloned halves of cytomegalovirus assemblin, An and Ac, can restore proteolytic activity to assemblin mutants by intermolecular complementation.
Journal of virology - 1 Feb 1997
Hall M R, Gibson W
Abstract excerpt
Herpesviruses encode an essential serine proteinase called assemblin that is responsible for cleaving the precursor assembly protein during the process of capsid formation. In cytomegalovirus (CMV), assemblin undergoes autoproteolysis at an internal (I) site located near the middle of the molecul...
Topics
- Cytomegalovirus
- Endopeptidases
- Enzyme Activation
- Humans
- Mutation
- Recombinant Proteins
- Serine Endopeptidases