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Article

Interleukin-1 beta converting enzyme requires oligomerization for activity of processed forms in vivo.

The EMBO journal - 1 May 1995

Gu Y, Wu J, Faucheu C, Lalanne J L, Diu A, Livingston D J, Su M S

Abstract excerpt

Interleukin-1 beta converting enzyme (ICE) is composed of 10' (p10) and 20 kDa (p20) subunits, which are derived from a common 45 kDa precursor. Recent crystallographic studies have shown that ICE exists as a tetramer (p20/p10)2 in the crystal lattice. We provide evidence that the p10 and p20 subunits of ICE associate as oligomers in transfected COS cells. Using intragenic complementation, we show that the...

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Identifiers

PMID: 7743999
DOI: 10.1002/j.1460-2075.1995.tb07184.x
PMCID: PMC398291

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