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Article

Trans complementation of variant Cre proteins for defects in cleavage and synapsis.

The Journal of biological chemistry - 29 Sept 2000

Shaikh A C, Sadowski P D

Abstract excerpt

The Cre recombinase is a member of the integrase family of conservative site-specific recombinases. These proteins share five conserved catalytic residues, one of which is a tyrosine that acts as the nucleophile to attack the scissile phosphodiester bond in the DNA target. Recombination by the Cre recombinase takes place in a supramolecular structure called a synapse that consists of four molecules of Cre bound...

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Identifiers

PMID: 10903322
DOI: 10.1074/jbc.M005256200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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