Article
The N- and C-terminal autolytic fragments of CAPN3/p94/calpain-3 restore proteolytic activity by intermolecular complementation.
Proceedings of the National Academy of Sciences of the United States of America - 23 Dec 2014
Ono Yasuko, Shindo Mayumi, Doi Naoko, Kitamura Fujiko, Gregorio Carol C, Sorimachi Hiroyuki
Abstract excerpt
CAPN3/p94/calpain-3, a calpain protease family member predominantly expressed in skeletal muscle, possesses unusually rapid and exhaustive autolytic activity. Mutations in the human CAPN3 gene impairing its protease functions cause limb-girdle muscular dystrophy type 2A (LGMD2A); yet, the connection between CAPN3's autolytic activity and the enzyme's function in vivo remain unclear. Here, we demonstrated that...
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