Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cytomegalovirus assemblin (pUL80a): cleavage at internal site not essential for virus growth; proteinase absent from virions.

Journal of virology - 1 Sept 2002

Chan Chee-Kai, Brignole Edward J, Gibson Wade

Abstract excerpt

The human cytomegalovirus (HCMV) maturational proteinase is synthesized as an enzymatically active 74-kDa precursor that cleaves itself at four sites. Two of these, called the maturational (M) and release (R) sites, are conserved in the homologs of all herpesviruses. The other two, called the internal (I) and cryptic (C) sites, have recognized consensus sequences only among cytomegalovirus (CMV) homologs and are...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomes, Artificial, Bacterial
Share to Cytomegalovirus

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cytopathogenic Effect, Viral

Share to Endopeptidases

Share to Serine Endopeptidases

Share to Transfection

Share to Virion

Share to Virus Assembly

Source

Open in PubMed Open full text

Identifiers

PMID: 12163586
DOI: 10.1128/jvi.76.17.8667-8674.2002
PMCID: PMC136994

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cytomegalovirus assemblin (pUL80a): cleavage at internal site not essential for virus growth; proteinase absent from virions.PMID 12163586Read ↗

Initial characterization of autoprocessing and active-center mutants of CMV proteinase.Semantic proximity Read ↗

The human cytomegalovirus terminase complex as an antiviral target: a close-up viewSemantic proximity Read ↗

Dissecting human cytomegalovirus gene function and capsid maturation by ribozyme targeting and electron cryomicroscopySemantic proximity Read ↗

Independently cloned halves of cytomegalovirus assemblin, An and Ac, can restore proteolytic activity to assemblin mutants by intermolecular complementation.Semantic proximity Read ↗

The protease of herpes simplex virus type 1 is essential for functional capsid formation and viral growth.Semantic proximity Read ↗

Assembly and maturation of the bacteriophage lambda procapsid: gpC is the viral protease.Semantic proximity Read ↗

Distinct and separate roles for herpesvirus-conserved UL97 kinase in cytomegalovirus DNA synthesis and encapsidationSemantic proximity Read ↗

Interaction of human cytomegalovirus pUL52 with major components of the viral DNA encapsidation network underlines its essential role in genome cleavage-packagingSemantic proximity Read ↗

Separate functional domains of the herpes simplex virus type 1 protease: evidence for cleavage inside capsids.Semantic proximity Read ↗

Sequences within the herpesvirus-conserved pac1 and pac2 motifs are required for cleavage and packaging of the murine cytomegalovirus genome.Semantic proximity Read ↗

Poliovirus capsid proteins derived from P1 precursors with glutamine-valine cleavage sites have defects in assembly and RNA encapsidation.Semantic proximity Read ↗

Analysis of putative active site residues of the poliovirus 3C protease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.