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Article

Disruption of a salt bridge dramatically accelerates subunit exchange in duck delta2 crystallin.

The Journal of biological chemistry - 24 Sept 2004

Yu Bomina, Paroutis Paul, Davidson Alan R, Howell P Lynne

Abstract excerpt

Intragenic complementation is a unique property of oligomeric enzymes with which to study subunit-subunit interactions. Complementation occurs when different subunits, each possessing distinct mutations that render the individual homomutant proteins inactive, interact to form a heteromutant protein with partial recovery of activity. In this paper, complementation events between human argininosuccinate lyase (ASL)...

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Identifiers

PMID: 15273245
DOI: 10.1074/jbc.M405300200

Genes

ASL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Disruption of a salt bridge dramatically accelerates subunit exchange in duck delta2 crystallin.PMID 15273245Read ↗

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Intragenic complementation at the human argininosuccinate lyase locus. Identification of the major complementing alleles.Semantic proximity Read ↗

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