Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Complementation between HIV integrase proteins mutated in different domains.

The EMBO journal - 1 Aug 1993

van Gent D C, Vink C, Groeneger A A, Plasterk R H

Abstract excerpt

HIV integrase (IN) cleaves two nucleotides off the 3' end of viral DNA and integrates viral DNA into target DNA. Previously, three functional domains in the HIV IN protein have been identified: (i) the central catalytic domain, (ii) the C-terminal DNA binding domain, and (iii) the N-terminal region, which is also necessary for activity. We have now investigated whether IN proteins mutated in different domains can...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Binding Sites
Share to DNA Nucleotidyltransferases
Share to DNA, Viral

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Complementation Test

Share to Integrases

Share to Mutation

Share to Sequence Deletion

Source

Open in PubMed Open full text

Identifiers

PMID: 8344263
DOI: 10.1002/j.1460-2075.1993.tb05995.x
PMCID: PMC413593

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Complementation between HIV integrase proteins mutated in different domains.PMID 8344263Read ↗

Complementation of integrase function in HIV-1 virions.Semantic proximity Read ↗

Genetic Analyses of Conserved Residues in the Carboxyl-Terminal Domain of Human Immunodeficiency Virus Type 1 IntegraseSemantic proximity Read ↗

Minimal core domain of HIV-1 integrase for biological activity.Semantic proximity Read ↗

Human Immunodeficiency Virus Type 1 Integrase Protein Promotes Reverse Transcription through Specific Interactions with the Nucleoprotein Reverse Transcription ComplexSemantic proximity Read ↗

Targeting human immunodeficiency virus (HIV) type 2 integrase protein into HIV type 1.Semantic proximity Read ↗

Mutations in the C-terminal domain of ALSV (Avian Leukemia and Sarcoma Viruses) integrase alter the concerted DNA integration process in vitro.Semantic proximity Read ↗

Site-directed mutagenesis of HIV-1 integrase demonstrates differential effects on integrase functions in vitro.Semantic proximity Read ↗

Functional analyses of mutants of the central core domain of an Avian Sarcoma/Leukemia Virus integrase.Semantic proximity Read ↗

Sequential Deletion of the Integrase (Gag-Pol) Carboxyl Terminus Reveals Distinct Phenotypic Classes of Defective HIV-1Semantic proximity Read ↗

Analysis of conserved and non-conserved amino acids critical for ALSV (Avian leukemia and sarcoma viruses) integrase functions in vitro.Semantic proximity Read ↗

Mutational analyses of the core domain of Avian Leukemia and Sarcoma Viruses integrase: critical residues for concerted integration and multimerization.Semantic proximity Read ↗

Mutational scan of the human immunodeficiency virus type 2 integrase protein.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.