Article
Complementation between HIV integrase proteins mutated in different domains.
The EMBO journal - 1 Aug 1993
van Gent D C, Vink C, Groeneger A A, Plasterk R H
Abstract excerpt
HIV integrase (IN) cleaves two nucleotides off the 3' end of viral DNA and integrates viral DNA into target DNA. Previously, three functional domains in the HIV IN protein have been identified: (i) the central catalytic domain, (ii) the C-terminal DNA binding domain, and (iii) the N-terminal regi...
Topics
- Binding Sites
- DNA Nucleotidyltransferases
- DNA, Viral
- Genetic Complementation Test
- HIV-1
- HIV-2
- Integrases
- Mutation
- Retroviridae Proteins
- Sequence Deletion