Article
Intragenic complementation at the argininosuccinate lyase locus: reconstruction of the active site.
Journal of inherited metabolic disease - 1 Jan 1998
Howell P L, Turner M A, Christodoulou J, Walker D C, Craig H J, Simard L R, Ploder L, McInnes R R
Abstract excerpt
Intragenic complementation has been observed at the argininosuccinate lyase (ASL) locus and the ASL alleles in the ASL-deficient cell strains of two complementation phenotypes have been identified. The frequent complementers, strains that participate in the majority of the complementation events,...
Topics
- Animals
- Argininosuccinate Lyase
- Binding Sites
- COS Cells
- Crystallins
- Genetic Complementation Test
- Models, Biological
- Models, Molecular
- Multigene Family
- Mutation
- Phenotype
- Structure-Activity Relationship