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Article

Intragenic complementation at the argininosuccinate lyase locus: reconstruction of the active site.

Journal of inherited metabolic disease - 1 Jan 1998

Howell P L, Turner M A, Christodoulou J, Walker D C, Craig H J, Simard L R, Ploder L, McInnes R R

Abstract excerpt

Intragenic complementation has been observed at the argininosuccinate lyase (ASL) locus and the ASL alleles in the ASL-deficient cell strains of two complementation phenotypes have been identified. The frequent complementers, strains that participate in the majority of the complementation events, were found to be either homozygous or heterozygous for the Q286R allele, while the high-activity complementers, those...

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Identifiers

PMID: 9686346
DOI: 10.1023/a:1005361724967

Genes

ASL

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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