Article
Overlap of interaction domains indicates a central role of the P protein in assembly and regulation of the Borna disease virus polymerase complex.
The Journal of biological chemistry - 31 Dec 2004
Schneider Urs, Blechschmidt Kareen, Schwemmle Martin, Staeheli Peter
Abstract excerpt
The active polymerase complex of Borna disease virus is composed of the viral proteins N, P, and L. The viral X (negative regulatory factor) protein acts as a regulator of polymerase activity. Interactions of P with N and X were previously studied, but interactions with L were poorly defined. Using a mammalian two-hybrid system, we observed that L specifically interacts with P but not with N, X, or itself....
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